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Description

Transcriptomic profiling showed that provision of either glutamine or glucose alone was insufficient to induce genes involved in fatty-acid and cholesterol biosynthesis/uptake (e.g., SREBF1/2 , ACLY , ACACA , FASN , SCD1 , HMGCR and LDLR )

Langmuir 35 , 69396949 (2019)

Tumour-specific irAEs and clinical outcomes A mechanistic link was proposed by the investigators of a prospective cohort study in which 73 NSCLC patients treated ICI showed that there was shared cancer and tissue antigens and T cell infiltration in both the lung tumour and the skin, suggesting an overlap between the toxicities and the efficacy [44]