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However, there is currently no consensus on the optimal reference intake levels of selenium, primarily due to the insufficient epidemiological data regarding the dose-response link between selenium and certain health effects

Intestinal microbial imbalance can affect the function of the HPA axis, leading to systemic inflammation and immune dysfunction

MJDs, machado-josephin domain proteases

doi: 10.1136/jmg.2004.022004 99 ChangYCLiuPHTsaiYCChiuYFShihSRHoLTet al

Acknowledgements This work was supported by the National Key Research and Development Program of China (2024YFC2418800, 2022YFC2504300), the National Natural Science Foundation of China (92468107, 82422045, 82102593, and 82402814), the Capitals Funds for Health Improvement and Research Program by Beijing Municipal Health Commission (2024-2-5052), the Beijing Natural Science Foundation (L256032, 7262117), PLA General Hospital Youth Independent Innovation Science Fund project (22QNFC041), and the China Postdoctoral Science Foundation (XJ2021051)