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Several metabolic intermediates, such as long-chain acylcarnitines can cause oxidative stress at high levels and high levels of ROS can then cause damage to cells and tissues, leading to a further decline in performance

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Overall, the biological processes in the human liver where proteins of the human HPX interactome are involved include regulation of lipid metabolism (regulation of lipase activity, cholesterol homeostasis), receptor-mediated endocytosis, immune system activation (complement activation, antibacterial humoral response, defense response to bacterium), and regulation of coagulation and wound healing

"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis"

Yoshida Y, Noshiro M, Aoyama Y, Kawamoto T, Horiuchi T, Gotoh O