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The role of HGF/Met signaling in proliferation, metastasis, and angiogenesis has been investigated in HNSCC, leading to clinical trials with various Met inhibitors and HGF antibodies

Although rare, both drugs can cause peripheral vasculopathy, which is a problem with blood vessels of the fingers, hands, legs, and feet

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The following diagram illustrates this compound's primary signaling pathways and their relationships in circadian regulation: The pineal gland serves as the central transducer of photic information into endocrine signals, primarily through melatonin synthesis [5]