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Among 17,604 adults with overweight or obesity (BMI 27) and established cardiovascular disease but without diabetes, weekly semaglutide cut the primary composite of cardiovascular death, non-fatal heart attack or non-fatal stroke by about 20% reaching 6.5% of the semaglutide group versus 8.0% on placebo, a hazard ratio of 0.80 (95% CI 0.720.90) (PMID 37952131)

Although it is known that abnormal lipid metabolism and adipose tissue accumulation possibly play important roles in linking obesity and T2D, the actual mechanisms are still unclear because not all obese people are insulin resistant or at high risk of diabetes [9]

In the face of vitamin B 12 deficiency, conversion of methylmalonyl-CoA to succinyl-CoA cannot take place, which results in accumulation of methylmalonyl-CoA and aberrant fatty acid synthesis

Currently, scientists have identified 15 types of B-thymosin, with thymosin Beta-4, or TB4, being the most abundant form

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