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The nuclear factor-kappa B (NF-B) transcription factor has been identified as the key factor during inflammation which can be stimulated by oxidative stimuli

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Moreover, recent mechanistic data has shown that quercetin-mediated stimulation of the Nrf2-ARE signaling axis is not only associated with antioxidant gene transcription but also coordinated regulation of phase II detoxifying enzymes, mitochondrial defence and inhibition of lipid peroxidation cascade, all of which enhances cytoprotective responses in tissue micro-environments of burn-damaged tissues