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Although the nanoparticle drug delivery system was not initially designed for LDL-receptor-mediated brain targeting, it was later found that apolipoprotein E would be absorbed on the polysorbate 80 coated nanoparticles upon incubation of the nanoparticles with human plasma resulting in LDL-receptor mediated BBB crossing

They're more easily absorbed into the body than oral supplements, which is why they're being prescribed by doctors more frequently

Subcutaneous B12 Injection Locations Subcutaneous injections involve administering the B12 solution into the fatty layer of tissue just beneath the skin

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Aug 1991;100(8):647-9