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It has been shown that AR protects against hydrogen peroxide-induced L02 cell damage, and the mechanism may involve oxidative stress

The administration of melatonin significantly enhanced the expression of SIRT1, thereby promoting SOD2 activity and expression through its involvement in histone deacetylation

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Yet, despite its relevance, the relationship of betaine and choline to homocysteine metabolism has been only lightly investigated in humans, essentially because the choline content of foods could not be accurately measured until fairly recently