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CSCs from melanoma [54], breast [54], lung [55], oral squamous cell [56], and ovarian [57] cancers have also been reported to be affected by 4-methylumbelliferone, along with tolerable systemic toxicity

Additionally, low level (10 M) H 2 O 2 treatment induced JNK-mediated FOXO3a translocation and activation to promote AKT-mediated stem cell proliferation, which when transplanted, increased re-epithelialisation and angiogenesis in wounded mice 147

Our results show that the designed lipophilic peptides can be spontaneously embedded in the lipid layer of the carrier, which recognizes the TMD of the target receptor in a manner similar to the interactions between TMDs

Clin Chim Acta 37:193197