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At the gene level, the expression levels of two representative human genes (i.e., BMPR2 , associated with pulmonary hypertension 59,60 , and HIF1A , changes in gene expression are associated with high-altitude hypoxia adaptation 91,92 exhibited significantly high correlations in relevant tissues between human and sheep (Fig

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canettii C59 was achieved using the BAC-recombineering (BAC-rec) strategy 53

These results highlight that caution needs to be applied to translating in vitro results where complete blocks to metabolic pathways can be achieved to in vivo situations where these pathways may only be partially inhibited

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