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What they did: A two-phase study, first in a dish with human endothelial cells (HUVECs), then in a live rat with an ischemic limb (= they closed off the artery so that no blood reached the leg)

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One of GLP-1 primary effects is slowing gastric emptying, the rate at which food moves from the stomach into the small intestine

Semaglutide with pyridoxine versus tirzepatide with B6 Tirzepatide (the active ingredient in brand-name Mounjaro and Zepbound) is a dual GIP/GLP-1 receptor agonist that has shown even greater weight loss efficacy than semaglutide in head-to-head trials