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Ultrastructurally, three types of cytoplasmic inclusions have been described: dense reticulated substance in the dilated cisternae of rough endoplasmic reticulum, fine granular substance in rough endoplasmic reticulum, and nonmembrane bound dense granulofibrillar in the cytoplasm (Helyer and Petrelli 1978)

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Groups that may benefit include: Individuals with high energy demands due to work or exercise Those following vegan or vegetarian diets, which can be low in B12 Older adults, as B12 absorption can decrease with age B12 and Folic Acid Combination Injections Healthcare providers might suggest combination injections for low B12 and folic acid levels

[DOI] [PMC free article] [PubMed] [Google Scholar] Wu JQ, Kosten TR, Zhang XY