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The aberrant neurotransmission is associated with several structural and functional changes in the brain and other encephalic structures, as it has been observed that patients with BD display abnormalities in neural circuitries supporting emotion processing, emotion regulation and reward processing [36]

VcGSTF128) subfamilies were the most abundant, together constituting over half of all VcGSTs, with the tau subfamily being the largest as commonly observed in higher plants

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The amplified gene was cloned into the pPT plasmid using the introduced restriction sites resulting in the plasmid pPT_ roGFP-iL (pLK9)

Phase I/II trials (first-in-human studies, testing doses and early effects) Elamipretide (Childrens Hospital of Philadelphia) pilot study conducted at CHOP