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When used in mice, the system strongly inhibited the growth of Ehrlich ascites tumor cells

Kaur R, Sood A, Lang DK, Arora R, Kumar N, Diwan V, et al

The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)