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The presence of EBV dUTPases may cause neurological abnormalities in ME/CFS via changes in gene expression, resulting in modulated neurological circuits (137)

Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer

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Esculetin , administered at 5 mg/kg in a rat model of TNBS-induced IBD, demonstrated potent intestinal anti-inflammatory effects, preventing an increase in MDA levels, countering GSH depletion, reducing epithelial cell apoptosis, and inhibiting the secretion of pro-inflammatory cytokines (IL-1, IL-2, IFN-) in vitro

Early clinical studies have demonstrated antitumor activity, highlighting the growing feasibility of targeting this historically challenging mutation