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a distant hydrophobic contact is observed between the side chain of P1-Ile and that of Cys70, which is involved in a disulphide bridge with Cys87

Ashe reportedly told Science, "I requested a correction for the 2006 paper, but it was rejected," adding that "retraction is the only option." In her most recent PubPeer post, Ashe also maintained that "the data manipulation does not change the experiment's conclusion that A*56 plays an important role in Alzheimer's disease."

Less commonly, Stevens-Johnson syndrome-toxic epidermal necrolysis and vesiculobullous dermatitis can occur with rituximab, in which case discontinuation is recommended

Concerns have been raised regarding the potential for abnormal cell growth, particularly in the absence of long-term safety data from clinical research

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