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Results: Adipose dysfunction disrupts metabolic homeostasis through complex molecular networks

Iron metabolism heavily relies on the interactions of iron response elements (IREs) and iron regulatory proteins (IRPs), collectively known as IRE-IRPs, to maintain cellular homeostasis

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For example, it has been shown that exceeding the upper limit of selenium intake (400 g/d) can lead to selenotoxicity, but no significant symptoms of toxicity were observed when selenium was ingested in the form of SeNPs (1,600 g/d), and some selenotoxicity symptoms did not occur until even an intake of 3,200 g/d (255)