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These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability

The matricellular phosphorylated glycoprotein osteopontin (OPN) is highly expressed in bone but is also secreted by a variety of cell types including endothelial cells, activated macrophages, leukocytes, and T cells (Murry et al., 1994

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Tumor volume was calculated using the following formula: tumor volume = (short length long length width)/2

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