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Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy

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Glutathione Transferase U13 functions in pathogen-triggered glucosinolate metabolism

Pan R, Debose L, Benito JM, Golfman LS, Zweidler-McKay PA, Han L, Harutyunyan KG, Mu H, Ruvolo VR, Park E, Muschen M, Leverson J, Borthakur G , Kantarjian HM, Ruvolo PP, Andreeff M, Konopleva M

This includes strategies that utilize iron chelatorswhich in specific contexts can inhibit ferroptosis by sequestering excess ironbut more commonly involves using iron ionophores or inducing ferritinophagy to increase intracellular free iron