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Gastroesophageal reflux disease and probiotics: A systematic review

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Another detailed aspect of combination therapy involves the use of TGF- inhibitors alongside agents targeting other key signaling pathways implicated in fibrosis, such as the Wnt/-catenin or PI3K/Akt pathways (128)

doi: 10.1016/S0928-4257(99)00119-9

Since ED is a common comorbidity in this group and patients often avoid reporting it actively due to a sense of shame, all male patients with genital involvement, high disease activity, or subjective reports of decreased QoL should be included in the systematic assessment