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Although cytotoxicity was not specific to homocysteine, endothelial cell detachment is also observed with cysteine (Dudman et al, 1991), an increase in the hydrogen peroxide-sensitive cellular fluorescent probe, 2,7-dichloro-fluorescein, was observed in cultured endothelial cells exposed to homocysteine (Toborek and Hennig, 1996)

Theyre more pronounced during the initial weeks of therapy as your immune system acclimates

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Important Safety Information Because isotretinoin can cause serious side effects, including birth defects, regular medical supervision is mandatory