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Furthermore, it has been suggested that cell damage may result in high plasma glutamine, due to leakage of intracellular glutamine from the destroyed cells into plasma [10], as intracellular glutamine concentrations greatly exceed plasma concentration in many tissues [25,26,27,28]

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Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways

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