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Cost to develop new pharmaceutical drug now exceeds $2.5 B

Frontiers in Medicine, 9 , 917146.

Advantages and disadvantages of different cell lines and different culture methods were shown in Fig

These ROS impair the structure and function of enzymes that regulate sarcoplasmic calcium levels, and through a chain reaction of free radical oxidation, including a decrease in the activity of antioxidant enzymes and the onset of an inflammatory response, may lead to lipid peroxidation and protein oxidation 69