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However, the clinical persistence of EMS, a disease state characterized by impaired mitophagy, suggests that the resulting elevation in ROS is not sufficient to induce widespread EESC death

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Lurie Children's Hospital of Chicago, 12 Riley Hospital for Children, 13 Hospital for Sick Children, 14 Children's Hospital Colorado, 15 Cincinnati Children's Hospital Medical Background: Hepatic decompensation from liver fibrosis is the primary indication for liver transplantation in patients with PSC