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The UGT enzymes of each family share at least 40% homology in DNA sequence, whereas members of UGT subfamilies exert at least 60% identity in DNA sequence (Burchell et al., 1995)

This System Xc /GSHGPX4 axis is thus a major ferroptosis pathway, with direct relevance to renal I/R injury

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

As noted by the authors, GSH can also directly participate in the formation of disulfide bonds necessary for antibody production and NADPH is necessary for continual lipid rearrangement required for Ig secretion 134,135