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PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans

See CJC-1295 vs Sermorelin

145 However, they found that even those aged 60 years, taking 2000 mg/day metformin and for 1 year had significantly reduced vitamin B12, indicating that this reduction started early in treatment for all ages and even with low doses