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The consequences of Cd hitting mitochondria include oxidative stress, the production of ROS, the start of apoptosis, the mutation of MTs-DNA, the modification of gene expression, the inhibition of respiratory chain complexes, the reduction of ATP synthesis, and the modification of endo-mitochondrial conductivity

Given that CRC cells with mutated PIK3CA are more dependent on glutamine, CB-839 (GLS inhibitor) combined with 5-fluorouracil (5-FU) can significantly induce CRC cell apoptosis when compared with the corresponding monotherapies (196)

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