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Xue-Chun Hu, [email protected] These authors have contributed equally to this work This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The most severe manifestation is stroke, resulting in varying degrees of neurological deficit