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While many synthetic polymers are bio-inert, they are frequently engineered to incorporate functional groups that allow cells to bind to and interact with the hydrogel (Peppas et al., Poly(ethylene glycol) Poly(ethylene glycol) hydrogels are a commonly used synthetic biomaterial for drug delivery (Peppas et al., To facilitate hydrogel formation, PEG can be crosslinked by two mechanisms: step-growth and chain-growth, or a combination of the two, termed mixed-mode

pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy

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Neurology 83 , 628637 (2014)

They start as red spots that hurt when touched, but they eventually grow in size and rupture, leaking fluids