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Fourth, animal models most commonly involve mice and rats but have also included ovine, porcine, and nonhuman primate models (Browne et al., 2011

We found that in all four groups of mice Muribaculaceae (~40%) , Lachnsopiraceae NK4A136 (~25%), and Akkremansia (~25%) comprised 75% of the relative abundance of bacterial taxa across all groups ( Fig.2 )

On the one hand, ferroptosis promotes osteoclast differentiation and inhibits Runx2-mediated osteoblast differentiation via the TfR1/ROS signaling axis, disrupting bone metabolic coupling and leading to subchondral bone instability, thereby exacerbating OA (Ru et al., 2023)

These effects may help enhance recovery and performance by protecting skeletal muscle tissue from damage caused by oxidative stress

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