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Fibroblast cultures are commonly used to measure transcriptional responses involving matrix-associated proteins, growth signaling regulators, and stress-response pathways

G can also modulate various signaling pathways and interact with target proteins

doi: 10.3389/fendo.2025.1613334 Received 17 April 2025 Accepted 15 August 2025 Published 02 October 2025 Volume 16 - 2025 Edited by Hong Liu, UC Davis Health, United States Reviewed by Andrei Adrian Tica, University of Medicine and Pharmacy of Craiova, Romania Tian Xia, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, China Updates Copyright 2025 Ou, Wang, Zhou, Chen, Lyu, Feng and Huang

Likewise in our previous studies of glaucoma, we have observed metabolic deficiency in the DBA/2J optic nerve that coincides with an early period of degeneration [69]