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Biol Res 42:315326 Scrutton NS, Berry A, Perham RN (1990) Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

Though non-specific, certain pathogenic factors including genetic predisposition, visceral hypersensitivity, food intolerance, altered gut-brain axis and gut dysmotility, dysfunction of innate immunity and dysbiosis may contribute to this disorder (Figure 1)

Our first set of simulations aimed to determine the relative rates of reaction for Gpx and GR, and hence, which of the two enzymes should be more highly expressed

This finding suggests a significant overlap in the mechanisms responsible for each type of pregnancy complication (170, 171, 174, 175, 181, 182)

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