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Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis

Written by Elena Brull, FNR, Functional Nutrition Researcher & Womens Health Journalist About the Author Elena Brull, FNR, is a Functional Nutrition Researcher and Womens Health Journalist specializing in integrative approaches to hormonal balance, nutrition, and longevity

At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

Cell death in all organs will contribute to illness and degeneration.This is a major cause of ageing

Modulation of dietary folate with age confers selective hepatocellular epigenetic imprints through DNA methylation