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Upon entering the cell, MPP+ inhibits the mitochondrial ETC Complex I enzyme, and NADH-ubiquinone oxidoreductase (EC 1.6.5.3), resulting in electron leakage and ROS generation in mitochondria [32]

Este estudio tambin mostr que los niveles de ingesta de colina estaban inversamente asociados con las concentraciones de homocistena en la sangre

This makes glutathione a preventive and therapeutic target rather than a rescue intervention

The eliminating organs, based on the drug's body clearance time, can readily remove the drug with no indication that the eliminating mechanisms are saturated

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