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GPX1 was present in selective glucagon cells and insulin cells, including in cells negative for both hormones, with stronger intensities in a higher percentage of glucagon than insulin cells

DNMT1 is the proposed maintenance methyltransferase that is responsible for copying DNA methylation patterns to the daughter strands during DNA replication

Previous studies have shown that the microbiota influences Th17 response in the gut [70], and that this intestinal inflammation can enhance pathogen colonization [71]

Additionally, these reactive species induce DNA oxidation, leading to mitochondrial and nuclear DNA mutations, further impairing ATP production and exacerbating ETC dysfunction

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