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The copper ion in GHK-Cu is not just along for the ride

After 11 days of ML226 treatment, we observed a marked increase in unsaturated tri- and diglycerides, with a downregulation of saturated glycerides (Extended Data Fig

This triggers a cascade reaction, releasing cytochrome c (Cyt c) into the cytoplasm and activating caspase-3, which may ultimately result in neuronal cell death (Riedl and Salvesen, 2007