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Acta Pharmacol Sin (2020) 41(4):52334

The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Heart Transplantation Report-2016

Introduction In the past 20 years great stress has been laid on the role of oxidative stress caused by reactive oxygen species (ROS), differences in antioxidant mechanisms among individuals, especially in age-dependent diseases such as cancer, arthritis, arteriosclerosis, neurodegenerative disorders and others (1,2)

Gene expression analysis revealed that posttransplantation ovarian gene expression profiles in mice closely resemble those of human ovarian tissue, suggesting that the POI microenvironment may induce MenSCss differentiation into ovarian-like cells (Liu et al., 2014)

By blocking NNMT, 5-Amino-1MQ prevents NAD+ breakdown , allowing its levels to rise