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Aggresome-like foci can be expelled within exophers Having established that specific aggresome components likely act cell autonomously to influence exopher levels, we asked whether aggresome-like inclusions can themselves be expelled in exophers, and if so, whether aggresome inclusion is mandatory for exopher formation

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By treating metabolically active adipocytes and hepatocytes with 5-amino-1-methylquinolinium, researchers can precisely inhibit intracellular NNMT activity, monitor changes in the nicotinamide pathway and NAD+ levels, and analyze effects on energy metabolism