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J.K., H.J.K., M.S.K., J.I.S

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THE EXTRACELLULAR MATRIX INCREASES INTERSTITIAL PRESSURE The ECM makes up ~50% of the dry weight of the tumor, which is about half of that in skin but twice the concentration found in peripheral nerve endoneurium

Lentivirus Vector Infection Lentiviruses expressing FTO, SLC7A11, FTO-shRNA (target sequences: gcAGCATACAACGTAACTTTG), SLC7A11-shRNA (target sequence: ccCTGGAGTTATGCAGCTAAT), scrambled shRNA, and empty vector were purchased from Genechem Company (Shanghai, China)

F., Kleinman, J