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180, 181 AG-211 has since been introduced into Phase I clinical trials and a Phase III trial has been initiated in 2015

Moderate glutathione synthetase deficiency Patients with the moderate variant usually present in the neonatal period with severe and chronic metabolic acidosis, 5-oxoprolinuria, and mild/moderate hemolytic anemia

Hortic Res

Indeed, it could be recently shown that the transporter formerly known as thylakoid ADP/ATP carrier TAAC ( papst1/taac loss-of-function mutant revealed an impairment of biosynthesis of sulfated compounds and involvement in sulfur metabolism ( papst1/taac mutant was shown to be slightly retarded in growth compared to corresponding wild-type plants (Col- 0 or WS- 4

Diagnostic methods The level of 5-oxoproline in urine can be determined by gas chromatography-mass spectrometry [26]