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Ashwagandha has revealed antidepressant-like properties in adolescent models of depression through the attenuation of apoptosis, reduction of neuroinflammation, and promotion of neurotrophic factors

This result might have wide implications for human health considering more than 30% of East Asians and over 540 million people worldwide have a dominant negative mutation in ALDH2 that reduces the activity of this enzyme (the ALDH2*2 polymorphism)

Biochim Et Biophys Acta (BBA)-Bioenergetics

Also, at higher doses, they can impair athletic performance by elevating body temperature and accelerating muscle breakdown

Nat Commun 5:4462