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Stem cell therapies may offer more comprehensive tissue regeneration capabilities through cellular replacement and differentiation, while these peptides may be simpler to administer and have fewer regulatory barriers in certain jurisdictions

Response: Based on the comment received, we do not believe that this medical device is used to deliver a therapy to reduce postoperative pain or produce post-surgical or regional analgesia because the supporting information provided demonstrates that this therapy is used to treat chronic low back pain associated with multifidus muscle dysfunction, rather than post-operative or post-surgical or regional analgesia

(2022) Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation Biomedicines, 2022 Oct 25;10(11):2696

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Layer 6 SST neuropeptide Y (NPY) INs were the only subtype to express all three IN-localised resilience-linked proteins, a subtype also highlighted by the same snRNA-seq study 14