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These subunits combine in various configurations to form functionally diverse receptor subtypes, with the 4 2 and 7 subtypes being the most representative in the central nervous system (CNS)

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doi: 10.3389/fneur.2026.1803045 Received 03 February 2026 Revised 21 May 2026 Accepted 31 May 2026 Published 17 June 2026 Volume 17 - 2026 Edited by Johannes Boltze, University of Warwick, United Kingdom Reviewed by Aleksandras Vilionskis, Vilnius University, Lithuania Jianwen Guo, Second Affiliated Hospital of Guangzhou Medical University, China Updates Copyright 2026 Utz, Miettinen, Bauelos-Cabrera, Lara-Valderrbano, Vlimaa and Harel

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This protocol maintains hepatic glutathione reserves rather than attempting to replenish them after depletion, which is a more realistic goal given the absorption limitations of oral formulations