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The MDA-MB-231 cells were seeded at a density of 1 10 5 cells per well in 96-well culture plates

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P53 induces the expression of spermidine/spermine N1-acetyltransferase 1(SAT1), and activation of SAT1 promotes the expression of arachidonate 15-lipoxygenase (ALOX15), thereby promoting the process of lipid peroxidation and thus ferroptosis [77]

That distinction is more important than most people realize because the Federal Food, Drug, and Cosmetic Act (FD&C Act) was designed to accomplish two important objectives

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