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Conventionally, injurious stimuli are often accompanied by inflammation

Authors contributions Analysis & interpretation of data (PJ, EB, ML), statistical analysis (PJ, EB, ML), manuscript writing (PJ, ML), critical revision (EB, ZY, MV, ML), material support (MV).

It inhibits class-I histone deacetylases, remodels chromatin and gene expression, activates an anti-inflammatory receptor, and competes with acetyl-CoA in anabolic reactions 264,379,380,381,382

MPS saturation, often observed even after a single high-dose nanoparticle administration, can temporarily impair macrophage-mediated clearance of subsequent particles or pathogens, though this effect is not always sustained [274]

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