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[DOI] [PubMed] [Google Scholar] 281.Li Y, Gao Y, Cui T, Yang T, Liu L, Li T, Chen J

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Most evidence comes from lab and animal studies, not controlled human trials

The drug-induced hypersensitization of the brain reward circuits is hypothesized to cause a pathological transition from drug liking to wanting that underlies compulsive substance use as previously demonstrated with chronic challenges of morphine, cocaine, ethanol, nicotine, and cannabinoids ( All mice were taken out from the IntelliCage once daily (in the morning) to receive their assigned 28-day drug sensitization regimen

S4A2 h TGF-stimulation), thus defining this pathway probably as the major mediator of the crosstalk between TGF- and c-MET