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Challenges and prospects in GBM therapy The treatment of GBM remains profoundly challenging in oncology because of the resilience and plasticity of GSCs, extensive tumor heterogeneity, the highly immunosuppressive TME, metabolic adaptability, and the BBB

The remaining approximately 25% of carnitine is synthesized endogenously, mainly in the liver, renal cortex, and brain astrocytes, from lysine and methionine [66]

It is important to understand that not every treatment will be suitable for every patient

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Peripheral and hepatic clearance of Tau protein and -synuclein Tau protein and -synuclein (-syn) aggregation are two additional neuropathological hallmarks of neurodegenerative disorders, including AD and Parkinsons disease (PD) [54, 55]