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EMG1, a ribosome biogenesis factor, emerged as the most highly upregulated protein, supporting the elevated biosynthetic phenotype of HMC3 cells (163)

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Maintenance of these structures are crucial, because the dysregulation of tight junction proteins during injurious events, such as in celiac disease or intestinal ischemia, and the inability to repair tight junction structures after injury can result in intestinal inflammation, sepsis, and multiple organ dysfunction in clinical patients (16, 17)