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HIF1 promotes MDSC activity and differentiation in the hypoxic-TME, as well as MDSC differentiation into TAMs [67]

Elderly, Cachectic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients (see WARNINGS, Life-Threatening Respiratory Depression)

Lee, S., Shin, H

It is estimated that CagriSema could hit the market by late 2025 or early 2026, pending the outcome of Novo Nordisk s phase 3 trials, expected later this year and in early 2025