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This interaction blocks p53-mediated apoptosis, allowing senescent cells to survive.57 FOXO4-DRI, a synthetic peptide, disrupts the FOXO4-p53 interaction, reactivating apoptosis and clearing senescent cells

Isotton AL, Wender MC, Casagrande A, Rollin G, Czepielewski MA

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2B right), and only minimally affected the ATP production of the TCGA-CONTROL dataset